Question
Which of the following reactions is appropriate for converting acetamide to methanamine?
A.
Carbylamine reaction
B.
Hofmann hypobromamide reaction
C.
Stephens reaction
D.
Gabriels phthalimide synthesis
Answer :
Hofmann hypobromamide reaction
Solution :
The conversion of amide with no substituent on nitrogen to an amine containing one carbon less by the action of alkaline hypobromide or bromine in presence of $$NaOH.$$ It involves the migration of alkyl or aryl group with its electron pair to electron deficient $$N$$ from adjacent carbon. The reaction involves the intermediates of isocyanate.
\[\text{Step V:}\,C{{H}_{3}}NCO+2O{{H}^{-}}\xrightarrow{\Delta }\] $$C{H_3}N{H_2} + CO_3^{2 - }$$
The conversion of amide with no substituent on nitrogen to an amine containing one carbon less by the action of alkaline hypobromide or bromine in presence of $$NaOH.$$ It involves the migration of alkyl or aryl group with its electron pair to electron deficient $$N$$ from adjacent carbon. The reaction involves the intermediates of isocyanate.
\[\text{Step V:}\,C{{H}_{3}}NCO+2O{{H}^{-}}\xrightarrow{\Delta }\] $$C{H_3}N{H_2} + CO_3^{2 - }$$